Monitoring the Spectrum of Candidemia and its Anti-fungal Resistance in A Tertiary Care Centre – An Emerging Global Alarm

Candidemia is caused by healthcare-associated bloodstream infections ranking as a fifth cause especially in the United States well European countries among intensive care units (ICUs). Despite ongoing advances diagnostics and medical interventions, it remains associated with high mortality rates, along prolonged duration of hospitalization elevated health costs. The aim study to characterize Candida species investigate antifungal resistance pattern from blood samples Tertiary Care centre. 53 known isolates various wards ICUs were collected. All are processed speciated conventional identification method demonstrating its virulence factors phenotypically AFST patterns studied. In present study, isolates, 25 (47.16%) C. tropicalis predominant pathogen followed 11 (20.75%) parapsilosis, 9 (16.98%) albicans, 4 (7.54%) glabrata krusei. Phospholipase activity was observed 30 (56.60%) 36 (67.92%) showed hemolysin production. 15 (28.30%) being resistant Fluconazole 2 (3.77%) Amphotericin B. prevalence candidemia high, fatality rate alarming non-albicans fluconazole least effective drug owing level resistance.